Genome editing is a flourishing tool that tends to be a boon for scientists to change an organism's DNA. With genome editing technology, scientists can add, remove or alter DNA, resulting in the inactivation of target genes, acquisition of novel genetic traits, and correction of pathogenic gene mutations. Different approaches were developed to edit the genome; one among them is CRISP-Cas which was recently developed. CRISPR associated proteins (CRISPR/Cas) are genome editing systems originated from prokaryotes that have allowed researchers to identify, photograph, alter, and annotate specific DNA and RNA sequences in a variety of living cells. Since using CRISPR/Cas is of low cost with high efficiency and good repeatability with a short cycle, it is used globally for genome editing. In the review, we analysed the utilisation of CRISPR/Cas as therapeutics to cure deadly diseases such as AIDS, Hepatitis B and human papillomavirus infection. Since CRISPR/Cas is cost-effective genome editing, the challenges to be faced in future due to usage of CRISPR/Cas and the areas where it can be utilised were discussed briefly in this review. Key message: Genetic technology, genome editing, editing tool, CRISPR/Cas, cost-effective, therapeutics.