Background: An increasing prevalence of cancer was globally reported, especially in developing countries like India, and early identification is more productive and lessens the economic burden on the subject, family and society. Healthcare professionals who were involved as first contact healthcare experts, especially musculoskeletal experts like Physiotherapists, Physicians, and Orthopedic surgeons, should be made aware of physical screening and associated psychosocial factors that could have a potential link for breast cancers, especially among women. Females with greater stress in life, having a systemic illness like Hypertension, Diabetes, having Chronic Polyarthralgia be continuously examined with physical, laboratory and due investigations exclusively for breast cancer once every three months. Every minor deviation from normalcy or suspicion is treated as a red flag and referred to experts. These clinical symptoms, like limbs getting stiffer, continuous pain over the spine with progressive movement restriction, changes in voice, and physical functioning with fatigue, were noted in a 60-year-old woman divorcee. Methodology: Since the age of 30 years with a highly stressful life, living with medication for Hypertension, Diabetes mellitus was referred by a physiotherapist to Gynecologist for her physiological changes as noted above on haematological and radiological examination revealed left ductal carcinoma of grade III was treated with left breast mastectomy and axillary clearance in 02/2019, she was later treated with physiotherapy, and again the influence of HRT on the musculoskeletal system was analysed with evidence. Conclusion: This research where an attempt at the early identification of breast carcinoma by the physiotherapist. Further, post-mastectomy, the response to exercises with HRT was analysed using due scientific evidence. The findings of this research can be a newer chapter for onco-physiotherapy to identify breast cancer clinically and up-date on exercise response with HRT.
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